低血鉀麻痺症之臨床研究

Hypokalemic Periodic Paralysis

許維志(Wei-Chih Hsu) ； 邱浩彰(Hou-Chang Chiu)

《台灣醫學》 2卷1期 (1998/01) Pp. 18-23

https://doi.org/10.6320/FJM.1998.2(1).03

摘要

針對20位低血鉀麻痺症患者分析，探討甲狀腺毒性與非甲狀腺毒性麻痺症在基本資料，臨床表現及實驗室數據的差異。兩組病人在發病及入院年齡、住院日期長短、CPK及GOT值、鉀離子補充總量有明顯差異；平均血鉀濃度沒有統計意義上的差別。因此，低血鉀麻痺症患者除檢驗甲狀腺功能外，對於年齡高，女性，CPK、GOT值過高，以及鉀離子補充量偏高而血鉀濃度仍低的病患，必須進一步安排其他檢查以了解真正致病機轉。

關鍵字

低血鉀麻痺症 ； 甲狀腺毒性 ； 遺傳性腎上腺增生 ； Bartter氏症候群 ； 原發性皮質醛酮分泌過多症

並列摘要

Thyrotoxic paralysis is the most frequent etiology of hypokalemic paralysis in Orientals. In order to study the differences between thyrotoxic and nonthyrotoxic hypokalemic paralysis, we retrospectively analyzed the records of 20 patients who presented with hypokalemic paralysis during a 5-year period. The etiologies included familial periodic paralysis, thyrotoxic periodic paralysis, excessive consumption of diuretics, primary hyperaldosteronism, Bartter’s syndrome, congenital adrenal hyperplasia, and alcoholism. There were one familiar periodic paralysis, ten thyrotoxic paralysis and nine nonthyrotoxic paralysis. All the patients in the thyrotoxic groupwere male, and three female in the nonthyrotoxic group. We compared various demographic and laboratory data between those with thyrotoxic and those with nonthyrotoxic paralysis. Patients with nonthyrotoxic paralysis were significantly older at the age of onset, were more often female, had longer durations of hospitalization, and more amount of potassium supplement required than those with thyrotoxic paralysis. Our findings show that age, sex, GOT and CPK values, and the amount of potassium supplement required are important in differentiating thyrotoxic from nonthyrotoxic hypokalemic paralysis.

並列關鍵字

hypokalemic paralysis ； thyrotoxic ； congenital adrenal hyperplasia ； Bartter's syndrome ； primary hyperaldosteronism