In problem-based learning (PBL), problems or cases are the driving force behind students’ independent learning in PBL. This places a high demand on the quality of problems used in order to achieve the desired learning outcome. This paper reports the initial experiences of a core group of faculty involved in designing cases for use in PBL tutorials in all three phases and the use of feedback comments from tutors to assist in improving the quality of the cases. In Phases I and II, a case is written based on broad learning objectives identified to address certain concepts selected within certain organ systems. In Phase IIIA, clinicians have written the cases within their disciplines with little or no input from basic scientists. A case evaluation form has been introduced for use with all PBL cases in the current 2001/2002 session in order to obtain feedback on the cases used. Tutors also list the learning objectives identified by their respective tutorial groups, and these are compared with the initial list of learning objectives on which the case was based. On the whole the two lists of learning objectives matched although students in phase I tended to be “distracted” by the clinical situation in the case and did not focus as well as intended on basic science concepts. In Phases II and III, the cases were appropriate for those levels and students did not seem to have much trouble in achieving the intended learning objectives. The use of feedback on PBL cased has been invaluable towards ensuring continuous improvement of the quality of cases and in case design.