Background: The most important task in education is reshaping the neural circuits in the brain. Through the process of deep emotional internalization, profound experience, repeated research to reshape our brains would break through existed frameworks and establish an education model that fits our own culture. Purpose: To find out practical ways to develop teaching and learning methods with regard to international recommendations and to local cultural context. Methods: By applying the CIPP model (Context, Input, Process and Product approach), a series of reforms in Taiwan medical education were reviewed in different aspects. Results: In Context session, Taiwan medical education history was reviewed to present the background of the evolution. The Input session described that how Taiwanese medical educators learned from recent reforms and evolutions in Western medical teaching and learning methods to extract their "essence" into the traditional system. The Process session introduced that how to blend western essence with the unique characteristics of East Asian educational culture and what obstacles were conquered. And the Product session addresses the outcome of Taiwanese medical education system evolution and reform in terms of different stages. Conclusion: From our experience, we demonstrated the practical ways to integrate cultural values and needs of medical students and teachers in developing our own teaching and learning methods.