Arterial Thrombosis in Nephrotic Syndrome

腎病症候群併發動脈栓塞

魏皓智(Hao-Ji Wei) ； 謝世榮(Shih-Rong Hsieh) ； 黎方中(Fon-Chung Lai) ； 蔡鴻文(Hung-Wen Tsai) ； 張燕(Yen Chang)

《Mid-Taiwan Journal of Medicine》 5卷2期 (2000/06) Pp. 120-124

https://doi.org/10.6558/MTJM.2000.5(2).8

摘要

過度凝血是腎病症候群患者常見的併發症。靜脈系統較常受影響，而動脈栓塞則較少見。患者截肢率及死亡率均相當高。多種因素都與此狀況下的血栓栓塞有關。我們報告一自發性之股動脈椎塞，手術去除栓塞之後又復發的病例。再次手術併使用新鮮冷凍血漿才成功地治癒此病例。我們建議，在治療腎病症候群患者之動脈椎塞時除了積極地血栓去除術及足量的抗凝血劑外，還應以新鮮冷凍血漿補充抗凝血酶。

關鍵字

抗凝血酶 ； 動脈栓塞 ； 腎病症候群

並列摘要

Hypercoagulability is a well-known phenomenon in patients with nephritic syndrome. It involves the venous system in most patients where arterial thrombosis is relatively rare. Only 47 cases of nephritic syndrome complicated with arterial thrombosis have been reported in the literature from 1948 through 1993. Both the mortality and morbidity rates are high. Multiple factors have been implicated in patients with thromboembolism in nephritic syndrome. We present a patient with spontaneous femoral artery thrombosis that recurred after successful embolectomy and anticoagulant therapy. Subsequent embolectomy followed by fresh frozen plasma (FFP) transfusions prevented further thromboembolism. We concluded that the management of arterial thrombosis in patients with nephritic syndrome requires aggressive replenishment of antithrombin Ⅲ with FFP and adequate heparinization in addition to surgical management.

並列關鍵字

antithrombin Ⅲ ； arterial thrombosis ； nephrotic syndrome