Detection of Esophageal Carcinoma by T1-201 SPECT Imaging

鉈-201單光子射出斷層掃描對食道癌的偵測

孫盛生(Shung-Shung Sun) ； 施志勳(Chih-Shiun Shih) ； 許南榮(Nan-Yung Hsu) ； 莊豐如(Feng-Ju Chuang) ； 林君宜(Chun-Yi Lin)

《Mid-Taiwan Journal of Medicine》 8卷1期 (2003/03) Pp. 37-41

https://doi.org/10.6558/MTJM.2003.8(1).7

摘要

目的：鉈-201(TI-20l)已是公認可被用來診斷癌症的藥物:然而利用鉈-201來診斷食道癌的研究卻很少被提出。因此，本研究目的在於評估鉈-201單光子射出斷層掃描對於偵測食道癌的敏感度。
方法：共選擇27位被診斷為食道癌病人來做胸部鉈-201單光子射出斷層掃描(21位是男性而6位是女性，年齡則從41歲到73歲)。其中21位病人是表皮樣癌而另6位則是腺癌。同時有10位(7位男性及3位女性，年齡由38歲到70歲)沒有胸腔疾病的正常人也接受此項檢查以做為對照組。
結果：在27位食道癌病人中，鉈-201單光子射出斷層掃描共24位(88.9%)出現陽性：而有3位(11.1 %)出現陰性，其中2位是表皮樣癌而另一位則是腺癌。而在對照組的10位正常人的檢查結果則都是陰性(100%)。
結論：本研究認為鉈-201單光子射出斷層掃描對於偵測食道癌是一項有用且不具侵犯性的檢查方法。

關鍵字

食道癌 ； 單光子射出斷層掃描 ； 鉈-201

並列摘要

Objectives: Thallium-20l (Tl-201) is a recognized tumor imaging agent; however, the usefulness of Tl-201 in esophageal carcinoma has rarely been studied. Therefore, we investigated the sensitivity and usefulness of TI-20l in detecting esophageal carcinoma.
Methods: A total of 27 patients (21 men and 6 women; age range: 41 to 73 years) with esophageal carcinoma underwent TI-201 single-photon emission computed tomography (SPECT) of the chest. Twenty-one of the patients had epidermoid carcinoma and six had adenocarcinoma. Meanwhile, 10 normal controls (7 men and 3 women; age range: 38 to 70 years) without any history of chest disease also underwent TI-201 SPECT of the chest for comparison.
Results: Tl-201 chest SPECT detected esophageal carcinoma in 24 patients (88.9%). However, two cases with known epidermoid carcinoma and one with adenocarcinoma were not detected in this study (11.1%). In contrast, all 10 normal controls (100.0%) had normal results with Tl-20l chest SPECT.
Conclusions: Our study suggests that the Tl-201 chest SPECT scan is a useful noninvasive imaging method for the detection of esophageal carcinoma.

並列關鍵字

esophageal carcinoma ； SPECT ； T1-201