應用於食道癌診斷之光學斷層攝影內視鏡系統

Endoscopic Optical Tomographic System for the Diagnosis of Esophageal Cancer

王于嘉(Yu-Jia Wang)

指導教授 ： 許怡仁

中原大學/理學院/物理研究所/碩士(2012年)

https://doi.org/10.6840/cycu201200462

摘要

本研究有兩個實驗系統，分別是食道檢體吸收光譜與光學斷層攝影內視鏡。
在食道檢體吸收光譜實驗系統中，利用二維自動平移臺掃描食道檢體，光譜儀取得其透射光譜，由透射光譜與已知的標準光譜計算出相關係數。本研究建立了此實驗系統並將其模組化成為可攜帶型的量測工具，並編寫此套系統的儀控與分析程式，可做為即時測量及分析食道檢體的癌化可能性。
在生物學中，光學斷層攝影術是新穎、高解析度及非侵入式的造影技術，在醫學上內視鏡廣泛用於診斷癌症和其他疾病。在光學斷層攝影內視鏡系統中，我們發展一新型的磁控掃描之內視探頭，並與光纖式頻域光學同調斷層攝影系統整合，藉由外部磁場的驅動使內視鏡探頭於樣品內做環狀掃描，以此取得表面下的二維斷層影像，並對影像做座標轉換。

關鍵字

吸收光譜 ； 內視鏡 ； 光學斷層攝影術

並列摘要

The objective of this research includes the investigation of absorption spectra of esophageal tissues and the development of an endoscopic optical tomographic system.
An optical system was designed and developed for two dimensional scanning of absorption spectra of esophageal tissues. The correlation between the absorption spectra of the samples and a standard spectrum was analyzed with an algorithm programmed with LabVIEW. This system was modulized to be a portable measurement tool. It can analyze the possibility of a tissue to be malignant after the measurement of absorption spectra.
On the other hand, optical coherence tomography (OCT) is a novel, high spatial–resolution, noninvasive imaging technique and has been widely used in biology and medicine. In clinical applications, endoscopes were widely used for diagnosis of cancer and other diseases. We designed and developed a fiber-based frequency-domain OCT system combined with a magnetic driving endoscopic probe which could provide two dimensional images of interested sample by rotating an external magnetic field.

並列關鍵字

absorption spectra ； endoscope ； optical coherence tomography

參考文獻

[1] G. A. Wagnieres, A. P. Studzinski, D. R. Braichotte, P. Monnier, C. Depeursinge, A. Chatelain, and H. E. van den Bergh, “Clinical imaging fluorescence apparatus for the endoscopic photodetection of early cancers by use of Photofrin II,” Appl. Opt., Vol. 36, pp. 5608-5620 (1997).

[2] T. Vo-Dinh, M. Panjehpour, B. F. Overholt, and P. Buckley III, “Laser-induced differential fluorescence for cancer diagnosis without biopsy,” Appl. Spec., Vol. 51, pp. 58-63 (1997).

[6] C. E. Pope II , “The esophagus for the nonesophagologist,” Am. J. Med., Vol. 103(5A), pp. 19S-22S (1997).

[9] N. Goseki, M. Koike, and M. Yoshida, “Histopathologic characteristics of early stage esophageal carcinoma,” Cancer, Vol. 69, pp. 1088-1093 (1992).

[10] C.A. Moskaluk, “Esophagus,” Modern Surgical Pathology (Second Edition), Vol.1, pp. 637-672 ( 2009) .