暴露二手菸懷孕婦女尿中1-OHP、2-NAP及可丁寧之濃度特性

Urinary Levels of 1-Hydroxypyrene, 2-Naphthol and Cotinine in Pregnant Women Exposed to Environmental Tobacco Smoke (ETS)

郭憲文(Hsien-Wen Kuo) ； 劉淑惠(Shu-Hui Liu) ； 周思源(Sze-Yuan Chou)

《Mid-Taiwan Journal of Medicine》 11卷1期 (2006/03) Pp. 28-34

https://doi.org/10.6558/MTJM.2006.11(1).4

摘要

目的　比較暴露二手菸之懷孕婦女尿中1-羥基芘(1-hydroxypyrene: 1-OHP)、2-萘酚(2-naphthol; 2-NAP)及可丁寧(cotinine)濃度。
方法　收集四所大型醫院產房中124名之生產婦女，以問卷方式得到其人口統計學及生活習慣等基本資料，並收集婦女尿液以高效能液相層析儀連接螢光偵測器(HPLC-Fluorescence)分析尿液中1-OHP及2-NAP濃度、而尿中之cotinine濃度則用HPLC-photodiol分析。
結果　暴露二手菸懷孕婦女尿中代謝物1-OHP、2-NAP及cotinine之濃度均較沒有暴露二手菸的婦女為高，除尿中cotinine濃度約高出20 mg/g cre.外，其他尿中1-OHP與2-NAP之濃度在兩組不具有統計顯著差異。這三種尿中生物指標濃度皆呈現正相關，1-OHP分別與2-NAP(r=0.14)、cotinine(r=0.09)及2-NAP與cotinine(r=0.12)相關性皆為正向，但均不具有統計顯著性之相關。
結論　暴露二手菸者以其尿中cotinine當作生物指標最明顯，而2-NAP亦可當作二手菸中暴露多環芳香碳氫化合物(PAHs)的尿中生物指標。

關鍵字

1-羥基芘(1-OHP) ； 2-奈酚(2-NAP) ； 可丁寧 ； 二手菸 ； 懷孕婦女

並列摘要

Purpose. To determine the urinary levels of 1-hydroxypyrene (1-OHP), 2-naphthol (2-NAP) and cotinine in pregnant women exposed to environmental tobacco smoke (ETS).
Methods. One-hundred twenty-four pregnant women from four hospitals were interviewed using a questionnaire. Data obtained included demographic information and life styles. The levels of 1-OHP and 2-NAP in urine specimens from all participants were analyzed by HPLC-Fluorescence; urinary cotinine levels were measured by HPLC-photodiol instrumentation.
Results. Urinary levels of 1-OHP, 2-NAP and cotinine in the ETS exposure group were higher than the non-exposure group; only urinary cotinine levels differed significantly between the two groups. Urinary levels of 1-OHP were positively correlated with 2-NAP (r=0.14) and cotinine (r=0.09), and 2-NAP and cotinine (r=0.12); however, no significant correlation was found.
Conclusions. Urinary cotinine and 2-NAP levels can be used as biomarkers to measure the exposure to poly aromatic hydrocarbons (PAH) emitted from burning cigarettes.

並列關鍵字

1-hydroxypyrene ； 2-naphthol ； cotinine ； environmental tobacco smoke ETS ； pregnant women