- 期刊
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血管張力素抑制劑改善心肌梗塞後心臟功能以及減少再塑形
Improved Left Ventricular Function and Reduction of Remodeling After Angiotension-Converting Enzyme Inhibitiors Therapy in Acute Myocardial Infarction
摘要
The purpose of this study was to evaluate the left ventricular global function and regional wall motion in patients with acute myocardial infarction MI after angiotension converting enzyme inhibitors treatment. Thirty-seven patients were enrolled in this study, aged 39 to 70 yr old. Seventeen cases of acute anteroseptal myocardial infarction (MI) received captopril 50 mg twice a day [the initial dose was 12.5 mg], as soon as possible MI. Two cases were withdrawed due to hypotension after therapy, and 3 cases were withdrawed due to severe cough after therapy. Twelve cases were randomly selected to be the control (conservative treatment). In the captopril group, 8 cases received percuttaneous transluminal coronary angioplasty (PTCA) later. In the control group, 12 cases received PTCA. Follow-up intravenous and/or intraventricular left cine-ventriculography, as well as radionuchlide ejection fraction were performed 6-12 months after the acute phase. The captopril group had a significant greater increase of ejection fraction by both the radionuclide (21±1.1 vs 5±0.6, P＜0.05) and intravenous (24±0.9% vs 6±9.5, P＜0.05) left ventriculography than the control group. There were no significant changes in the dyskinetic area, volume, and left ventricular circumference, between the 2 groups. The conclusion is that coptopril per os can improved the left ventricular function and prevent the remodeling and dilatation of It ventricle after acute myocardial infarction.
並列摘要
The purpose of this study was to evaluate the left ventricular global function and regional wall motion in patients with acute myocardial infarction MI after angiotension converting enzyme inhibitors treatment. Thirty-seven patients were enrolled in this study, aged 39 to 70 yr old. Seventeen cases of acute anteroseptal myocardial infarction (MI) received captopril 50 mg twice a day [the initial dose was 12.5 mg], as soon as possible MI. Two cases were withdrawed due to hypotension after therapy, and 3 cases were withdrawed due to severe cough after therapy. Twelve cases were randomly selected to be the control (conservative treatment). In the captopril group, 8 cases received percuttaneous transluminal coronary angioplasty (PTCA) later. In the control group, 12 cases received PTCA. Follow-up intravenous and/or intraventricular left cine-ventriculography, as well as radionuchlide ejection fraction were performed 6-12 months after the acute phase. The captopril group had a significant greater increase of ejection fraction by both the radionuclide (21±1.1 vs 5±0.6, P＜0.05) and intravenous (24±0.9% vs 6±9.5, P＜0.05) left ventriculography than the control group. There were no significant changes in the dyskinetic area, volume, and left ventricular circumference, between the 2 groups. The conclusion is that coptopril per os can improved the left ventricular function and prevent the remodeling and dilatation of It ventricle after acute myocardial infarction.
延伸閱讀
- Lin, C. F. (2020). 探討心肌梗塞後心肌纖維化的致病因子與組蛋白去乙醯酶抑制劑對心臟缺血再灌流損傷的影響 [doctoral dissertation, Taipei Medical University]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0007-2712201914422200
- Yin, Q. W. (2017). 抑制血栓素及血栓素受體訊號減輕血管內皮素-1及缺血再灌流所引起的心臟損傷 [master's thesis, National Taiwan Normal University]. Airiti Library. https://doi.org/10.6345/NTNU202202506
- 王勇、王偉、李國彰（2011）。氧化應激損傷回應在冠心病心肌缺血血瘀證中的實驗研究。臺灣中醫科學雜誌，5(2)，1-7。https://doi.org/10.29810/SJTTCM.201102.0001
- Adhyapak, S. M., Menon, P. G., Varghese, K., Mehra, A., Lohitashwa, S., & Fantini, F. (2017). Improvements in Regional Left Ventricular Function Following Late Percutaneous Coronary Intervention for Anterior Myocardial Infarction. Clinical Medicine Insights: Cardiology, 2017(), 1-7-017. https://doi.org/10.1177/1179546817746636
- Lin, J. F., Hsu, S. Y., Teng, M. S., Wu, S., Hsieh, C. A., Jang, S. J., Liu, C. J., Huang, H. L., & Ko, Y. L. (2016). Activin A Predicts Left Ventricular Remodeling and Mortality in Patients with ST-Elevation Myocardial Infarction. Acta Cardiologica Sinica, 32(4), 420-427. https://doi.org/10.6515/ACS20150415A