This research adopted the case study, one kind of the qualitative methods, investigated a gifted fourth grader with Asperger syndrome (Hsiao-Tan as assumed name). By participating Partial Acceleration Program using higher-level curricular materials, Hsiao-Tan took seventh grade Biology course. The research findings are as follows: (a) The acceleration experiences increased Hsiao-Tan engagement and motivation in self-realization and group work. (b) Hsiao-Tan learned the basic learning skills and strategies which never learned before. (c) Hsiao-Tan obtained more positive perception from his elementary school classmates and improved relationship with peers than before. (d) The short-term Partial Acceleration Program might not be effective at encouraging the interpersonal relationship between Hsiao-Tan and older peers. (f) The negative behaviors of Hsiao-Tan were easily observed, frustrated his teachers who cannot fully understand the twice-exceptional students. Finally, substantial suggestions for future studies and relative practice are proposed.