This study aims to explore the parenting stress and efficacy of a kinship parent (i.e., relative caregivers), who raises a middle school student with giftedness and Autism Spectrum Disorder (i.e., gifted ASD). This study used a case-study method to collect data of rating scales, qualitative interviews, and consultation records from the parent. The kinship parent's parenting stress was found to be in urgent need of professional referrals, and was related to the child's twice-exceptional characteristics and dysfunctional parent 'child interactions. Provision and continuum of social support were found to affect the mental health and parenting efficacy, which further changed the level of parental stress. Suggestions are given regarding Special counseling as well as advocacy for legislation and programs for kinship parenting.