New hot pepper variety 'TSS-AVRDC No.4' (previously breeding line COA258) was a hybrid first crossed in 2007. After a series of field trials, disease reaction evaluation, main component analysis, seed production, this F1 variety was named and granted with its plant variety right. It had plant medium-sized, semi-upright, and vigorous growth habit. The fruit, growing downwards, had two locules with about 15.4 cm in length, 1.6 cm in width and 15.7g in weight. The immature fruit was green, and turned red in color at maturity with mild soft skin and mild hot. It was resistant to potato virus Y (PVY), bacterial wilt (BW) and tolerance to anthracnose in the field, and suitable for growing season with high temperature and high humidity.