Background and objective: Workers in an Emergency Department (ED) are reputed to have a higher risk of becoming infected with tuberculosis (TB). This study was carried out to obtain epidemiological data on TB among nurses of TCVGH. This was then used to develop strategies to prevent TB infection in this group and allow an estimation of the relative risk of TB infection among nurses working in an ED versus nurses working in other environments at TCVGH. Subject and Methods: The study design was a cross sectional study. Their chest x ray (CXR) reports and TB status in 1998 were collected from their routine physical checkups and chart records. The exposure of the nurses to risk factors for TB infection were collected by a structured questionnaire. This asked for the basic data, whether they had cared for TB patients while working at other hospitals and their smoking habits. Results: Compared with non-ED nurses, ED nurses had a higher prevalence of active pulmonary TB, a higher prevalence of CXR detectable pulmonary TB. By multiple logistic regression analysis, the odds ratio of CXR detectable pulmonary TB for nurses with versus nurses without working exposure to ED was 2.59 (p=0.037, 95% Cl= [1.06, 6.34] ). Conclusion: (1) In TCVGH, compared with non-ED nurses, ED nurses had a higher risk of pulmonary TB. (2) It is clear that it is necessary that continual monitoring of this high-risk professional group for pulmonary TB be carried out.