【論文摘要】Effects of High-Intensity Interval Training and Moderate- Intensity Continuous Training on Circulating MicroRNAs in Sedentary Males

【論文摘要】高強度間隔式運動與連續中等強度運動對於坐式生活男性的循環性小分子核醣核酸之影響

陳冠銘(Kuan-Ming Chen) ； 黃瑾慧(Ching-Hui Huang) ； 王鐘賢(Jong-Shyan Wang)

《物理治療》 43卷2期 (2018/06) Pp. 132-132

https://doi.org/10.6215/FJPT.2018.75.O16

摘要

Background and Purpose: Circulating microRNAs (c-miRs) serve as the reliable biomarkers for intracellular mediators of processes inherent in exercise adaptation. The present study aimed to clarify the relationships between changes of c-miRs expressions and aerobic capacity/hemodynamic functions caused by various exercise regimens in men. Methods: Twenty-four healthy sedentary males were randomly engaged in either high-intensity interval training (HIIT, 3-minute intervals at 40% and 80% of VO_(2max), n = 12) or moderate-intensity continuous training (MICT, sustained 60% of VO_(2max), n = 12) for 30 minutes/day, 5 days/week for 6 weeks. Various c-miRs involved in angiogenesis (miR-126), cardiac hypertrophy (miR- 222, miR-221), and hypoxia/ischemia adaptation (miR- 21, miR-146a) were measured by quantitative real time polymerase chain reaction (qRT-PCR), respectively. Results: The analyzed results showed that both 6-week HIIT and MICT significantly enhanced VO_(2max), which were accompanied by increased stroke volume and cardiac output during exercise. Moreover, both HIIT and MICT increased expressions of miR-126 (1.49 ± 0.03 and 1.27 ± 0.09 folds) and miR-222 (1.32 ± 0.10 and 1.25 ± 0.15 folds), respectively. Furthermore, HIIT elevated miR-146a expression (1.33 ± 0.09 folds), whereas MICT upregulated miR-21 (1.32 ± 0.08 folds). However, no significant changes in plasma miR-221 level was occurred after both HIIT and MCT. Conclusion: We conclude that the exercise-induced cardiovascular adaptions are associated with the changes of angiogenesis/inflammation-related c-miRs following either HIIT or MICT. Clinical Relevance: We expect that this study can aid in determining appropriate exercise intervention for simultaneously improving aerobic fitness.