Diffuse Panbronchiolitis-A Case Report and Literatures Review

瀰漫性泛細支氣管炎－病例報告及文獻回顧

蔡偉宏(Woei-Horng Chai) ； 陳正雄(Cheng-Hsiung Chen) ； 蔡政宏(Cheng-Hung Tsai) ； 何上芸(Shang-Yun Ho)

《重症醫學雜誌》 11卷3期 (2010/10) Pp. 224-230

https://doi.org/10.30035/TCCM.201010.0009

摘要

瀰漫性泛細支氣管炎是一種慢性進行性阻塞性呼吸道疾病。臨床表現常見咳嗽有痰和呼吸困難，通常合併慢性鼻竇炎。瀰漫性泛細支氣管炎的病因不明，但大環內酯類藥物治療通常是非省有效的。我們報告一例案例，一位45歲的台灣籍女性病人診斷罹患瀰漫性泛細支氣管炎。病人的症狀是咳嗽和呼吸困難，經開始使用大環內酯類藥物克拉黴素治療後病情穩定控制。歷經4個月治療後，病人臨床症狀、肺功能、胸部X光及電腦斷層均顯著的改善。瀰漫性泛細支氣管炎有別於傳統的慢性阻塞性肺疾病，其病程可快速進展至支氣管擴張症併呼吸表竭；大環內酯類藥物克拉黴素是有效治療瀰漫性泛細支氣管炎的藥物。

關鍵字

瀰漫性泛細支氣管炎 ； 大環內酯類藥物

並列摘要

Diffuse panbronchiolitis (DPB) is a chronic progressive obstructive airway disease. Clinically, DPB is manifested by productive cough and dyspnea and commonly combined with chronic sinusitis. Despite that the etiology of DPB is unknown, macrolide treatment is usually effective. A case of 45 year-old Taiwanese patient female who had DPB was reported by us. The patient's symptoms of cough and dyspnea were controlled within four months after the initiation of macrolides treatment of clarithromucin. Marked improvements on pulmonary function testing, chest radiography and high resolution computed tomography were also apparent. It may be distinguished between DPB and traditional chronic obstructive pulmonary disease by its rapid progression and the associated development of bronchiectasis and respiratory failure. It can be suggested that macrolide of clarithromycin is an effective therapy for DPB.

並列關鍵字

Diffuse panbronchiolitis ； Macrolide