- 期刊
香椿葉萃取物對老化促進小鼠腦部氧化狀態及老化病理變化之影響
Effects of Toona sinensis Roemor Leave Extracts on Brain Oxidant Status and Aging Pathological Changes in Senescence Accelerated Mice
摘要
The objective of this study was to investigate the effects of Toona sinensis Roemor leave extracts on the brain morphological change and oxidant status in senescence accelerated mice prone-8 (SAMP8). Three-month-old male SAMP8 mice were divided into control (casein diet) and casein diet supplemented with0.5% Toona sinensis Roemor (TS) leave extracts for 12 weeks. The results showed that the body weight and food intake of TS diet group were not significantly different with the control group. The mice fed with TS extracts had significantly lower serum total cholesterol and triglyceride concentrations, and exhibited the decreasing malondialdehyde concentration in the striatum and cortex. Brain pathological examination showed that the TS supplement significantly lower the vacuoles numbers and the lipofuscin percentage in the hippocampus, and also reduced the percentage of β-amyloid protein deposition in the brain middle sections. It is suggested that the supplement of TS is effective to lessen the accumulations of lipid peroxidation product, and decrease the percentage of lipofuscin and β-amyloid of brain, possibly because the antioxdant capacity of TS.
並列摘要
The objective of this study was to investigate the effects of Toona sinensis Roemor leave extracts on the brain morphological change and oxidant status in senescence accelerated mice prone-8 (SAMP8). Three-month-old male SAMP8 mice were divided into control (casein diet) and casein diet supplemented with0.5% Toona sinensis Roemor (TS) leave extracts for 12 weeks. The results showed that the body weight and food intake of TS diet group were not significantly different with the control group. The mice fed with TS extracts had significantly lower serum total cholesterol and triglyceride concentrations, and exhibited the decreasing malondialdehyde concentration in the striatum and cortex. Brain pathological examination showed that the TS supplement significantly lower the vacuoles numbers and the lipofuscin percentage in the hippocampus, and also reduced the percentage of β-amyloid protein deposition in the brain middle sections. It is suggested that the supplement of TS is effective to lessen the accumulations of lipid peroxidation product, and decrease the percentage of lipofuscin and β-amyloid of brain, possibly because the antioxdant capacity of TS.