- 期刊
何首烏分層萃取物對老化促進小鼠腦部神經傳導物、氧化狀態及單胺氧化酶之影響
Effects of Polygonum multiflorum Thunb. Fraction Extracts on Brain Neurotransmitter, Oxidant Status and Monoamine Oxidase in Senescence Accelerated Mice
摘要
The purpose of this study was to examine the effects of different fraction extracts of Polygonum multiflorum Thunb. (PM) on brain oxidant status, neurotransmitters, monoamine oxidase and serum lipids in senescence accelerated mice. One-month-old mice were fed with a control diet, and either a diet supplemented with PM fraction extracted by ethyl acetate (EA), n-butanol (n-B) or water diets for 18 weeks. The results showed that the body weight, food intake, dopamine (DA), homovanillic acid (HVA) of the different PM fraction extract groups did not differ with the control group, whereas the 5-hydroxyindoleacetic acid (5-HIAA) and 5-HIAA/5-hydroxytryptamine (5-HT) ratio were higher than the control diet group (p＜0.05). The malondialdehyde (MDA) levels and monoamine oxidase-B activity of the hippocampus in the EA diet group were higher than the control group, while the n-B diet group had significantly lower triglyceride and total cholesterol concentration than the other groups. The results of this study indicated that the physiological function of PM need further study.
並列摘要
The purpose of this study was to examine the effects of different fraction extracts of Polygonum multiflorum Thunb. (PM) on brain oxidant status, neurotransmitters, monoamine oxidase and serum lipids in senescence accelerated mice. One-month-old mice were fed with a control diet, and either a diet supplemented with PM fraction extracted by ethyl acetate (EA), n-butanol (n-B) or water diets for 18 weeks. The results showed that the body weight, food intake, dopamine (DA), homovanillic acid (HVA) of the different PM fraction extract groups did not differ with the control group, whereas the 5-hydroxyindoleacetic acid (5-HIAA) and 5-HIAA/5-hydroxytryptamine (5-HT) ratio were higher than the control diet group (p＜0.05). The malondialdehyde (MDA) levels and monoamine oxidase-B activity of the hippocampus in the EA diet group were higher than the control group, while the n-B diet group had significantly lower triglyceride and total cholesterol concentration than the other groups. The results of this study indicated that the physiological function of PM need further study.
延伸閱讀
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- 魏一華（2005）。缺氧預處理與抗氧化物質對大鼠下位腦幹及結狀神經節內神經元及非神經元組成元素之影響〔博士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2005.00006
- 童思瑜（2017）。應用半自動 Bonfire程式分析神經樹突形態評估3,5-二甲基苯胺與其代謝物對於初代皮質神經元毒性之影響以及松杉靈芝對於老化大鼠認知功能障礙之改善效果〔碩士論文，中原大學〕。華藝線上圖書館。https://doi.org/10.6840/cycu201700628
- 張榮叁（2005）。The Biological Activity of Polygonum cuspidatum Sieb. et Zucc. against Hepatitis B Virus and Luteolin against Hepatocellular Carcinoma〔博士論文，高雄醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0011-2903200614024553
- Hsu, T. H., Lee, C. H., Lin, F. Y., Wasser, S. P., & Lo, H. C. (2014). The Fruiting Bodies, Submerged Culture Biomass, and Acidic Polysaccharide Glucuronoxylomannan of Yellow Brain Mushroom Tremella mesenterica Modulate the Immunity of Peripheral Blood Leukocytes and Splenocytes in Rats with Impaired Glucose Tolerance. Journal of Traditional and Complementary Medicine, 4(1), 56-63. https://doi.org/10.4103/2225-4110.124347