兒茶素對雄性老化促進小鼠學習記憶能力及肝臟抗氧化狀態之影響

Effects of Catechins on Learning and Memory Ability and Liver Antioxidant Status in Male Senescence Accelerated Mice

詹吟菁(Yin-Ching Chan) ； 陳如茵(Ru-Yin Chen) ； 廖俊旺(Jiunn-Wang Liao) ； 楊美都(Mei-Due Yang) ； 賴雅琪(Ya-Chi Lai) ； 王銘富(Ming-Fu Wang)

《臺灣農業化學與食品科學》 46卷2期 (2008/04) Pp. 78-86

https://doi.org/10.6578/TJACFS.2008.010

摘要

The objective of this study was to investigate the effects of catechins on the learning and memory ability and antioxidant status in male senescence accelerated mice prone-8 (SAMP8). Three and six month old SAMP8 mice were supplied with 50, 200, 800 ppm catechins or water as the solo drinking fluid for 12 weeks, The results shorted that the mice supplemented with catechins had significantly lower total grading score and better learning and memory ability. Catechins groups exhibited the decreasing malondialdehyde and protein carbonyls concentrations in liver, while the glutathione, total thiol, activities of catalase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase were significantly increased. Brain pathological examination showed that the catechins did not affect the β-amyloid protein deposition in the brain. In conclusion, the results suggested that the supplementation of catechins was effective on promoting the antioxidantive system, and decreasing the deterioration of learning and memory in SAMP8 mice.

關鍵字

兒茶素 ； 老化促進小鼠 ； 氧化狀態,學習記憶能力

並列摘要

The objective of this study was to investigate the effects of catechins on the learning and memory ability and antioxidant status in male senescence accelerated mice prone-8 (SAMP8). Three and six month old SAMP8 mice were supplied with 50, 200, 800 ppm catechins or water as the solo drinking fluid for 12 weeks, The results shorted that the mice supplemented with catechins had significantly lower total grading score and better learning and memory ability. Catechins groups exhibited the decreasing malondialdehyde and protein carbonyls concentrations in liver, while the glutathione, total thiol, activities of catalase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase were significantly increased. Brain pathological examination showed that the catechins did not affect the β-amyloid protein deposition in the brain. In conclusion, the results suggested that the supplementation of catechins was effective on promoting the antioxidantive system, and decreasing the deterioration of learning and memory in SAMP8 mice.

並列關鍵字

Catechins ； Senescence accelerated mice ； Antioxidant status ； Learning and memory