“海藻酸－鈣＂－凝膠球粒成型機制及影響性探討

Study on the Forming Mechanisms and Effects on the Calcium-alginate Hydrogel Beads

蘇柏駿(Po-Chun Su) ； 林奕廷(Yi-Ting Lin) ； 林宏昇(Hong-Sheng Lin) ； 江伯源(Po-Yuan Chiang)

《臺灣農業化學與食品科學》 50卷1期 (2012/02) Pp. 12-23

https://doi.org/10.6578/TJACFS.2012.002

摘要

軛海藻酸鈉（sodium alginate）為親水性高分子聚合物，溶於水中呈半透明均勻黏稠膠體溶液，藉由與鈣離子作用後可形成不溶性之海藻酸鈣凝膠。其於微膠囊技術（microencapsulation）上可作為一成膜材料，籍凝膠造粒技術包埋液體或固體之核蕊素材形成凝膠球粒，常見於藥品和食品工業上，本試驗擬透過微膠囊凝膠法，製備凝膠球粒，並以海藻酸納濃度、氯化鈣濃度、空氣流速，及固化時間等控制因子，探討海藻酸鈣凝膠球粒成型機制及影響性。試驗結果如下，製備凝膠球粒方面，適當延長固化時間（60-120 min），並提高海藻酸納濃度（3-5％）及氯化鈣濃度（0.3-0.5M）的條件下，可得完整粒狀且外表呈現飽滿之球體；藉自空氣流速的調整，膠球大小可有效的控制，但空氣壓力太大則會導致外觀成形較不規則。透過示差熱掃描分析，適當固化時間，能促進海藻酸納與鈣離子鍵結強度，由傅立葉紅外線掃描結果可知1590～1750 cm（上標 -1）屬於C=O官能基的共軛結，為影響鍵結作用之波峰位置。

關鍵字

海藻酸鈣 ； 凝膠球粒 ； 鍵結強度 ； 傅立葉紅外線掃描

並列摘要

Sodium alginate is a type of hydrophilic polymer and shows a translucent homogeneous viscous colloidal solution when dissolved in water. After binding with the calcium ions, insoluble calcium-alginate hydrogel will be formed. It can be used as a membrane-forming raw material in the microencapsulation technology which is often used in pharmaceuticals and food industries. In this study, the microencapsulation coacervation method was used to prepare the hydrogel beads and the control factors, such as concentration of sodium alginate, concentration of calcium chloride, air-flow rate and curing time were manipulated to study the forming mechanisms and effects of these factors on the formation of the calcium-alginate hydrogel beads. The results showed that when the hydrogel beads were prepared at appropriate extension of the curing time (60-120 min), and increased concentration of sodium alginate (3-5%) and calcium chloride (0.3-0.5 M), complete particles with smooth spherical appearance will be produced. The size of the hydrogel beads could be effectively controlled through the adjustment of air-flow speed. However, high air pressures would cause irregular shapes. The differential scanning calorimetry indicated that appropriate curing time could enhance the binding strength of the sodium alginate and calcium ions. From the fourier transform infrared spectroscopy (FT-IR) results, it was found that 1590～1750 cm^(-1) belonging to the conjugated structure of the C＝O functional group is the peak position that affects the binding effect.

並列關鍵字

Calcium-alginate ； Hydrogel beads ； Binding strength ； FT-IR