益生菌磷脂質微脂體複方產品改善胃腸道機能性之研究

The Improvement Effects of Probiotic and Phospholipid Liposomes Composite Products on Function of Gastrointestinal Tract

余乘安(Cheng-An Yu) ； 鄭孟純(Meng-Chun Cheng) ； 劉德華(Te-Hua Liu) ； 蔡宗佑(Tsung-Yu Tsai)

《臺灣農業化學與食品科學》 59卷4期 (2021/12) Pp. 107-117

https://doi.org/10.6578/TJACFS.202112_59(4).0001

摘要

胃腸道為人體中最大之消化器官同時亦為人體最大之免疫器官，其功能好壞對個體健康扮演著相當重要的角色。然而當個體進入老年期，人體機能會逐漸衰退，腸道機能亦會有老化之情況。本研究將於動物模式中探討磷脂質微脂體與Lactobacillus plantarum組合成之複方產品對便祕與結腸炎是否具有改善之效果。結果顯示，便祕大鼠經餵食不同劑量之複方產品後，與誘導組相比其直腸末端之糞便數量有降低之趨勢，其中又以L-5X組之大鼠糞便數量最低（5.00 ± 2.10顆；p ＜ 0.05）。餵食不同複方產品之結腸炎小鼠於試驗第18天開始，其疾病活動指數即出現顯著低於葡聚糖硫酸鈉（dextran sulfate sodium, DSS）誘導組之趨勢 （p ＜ 0.05）。此外，餵食不同劑量之複方產品可顯著降低結腸炎小鼠結腸組織中丙二醛含量；同時亦可顯著增加超氧化物歧化酶活性（p＜ 0.05）。進一步檢測促發炎激素，結腸炎小鼠經餵食1X複方產品後，其結腸中腫瘤壞死因子-α（tumor necrosis factor-α）、介白素（interleukin, IL）-1β及IL-6含量顯著低於DSS誘導組（p ＜ 0.05）。綜上所述，複方產品具有改善便秘或減緩結腸炎之潛能。

關鍵字

胚芽乳酸桿菌 ； 磷脂質微脂體 ； 便祕 ； 結腸炎 ； 胃腸道機能性

並列摘要

The gastrointestinal tract is not only the largest digestive organ but also the organ with the largest surface area in the human body. The functions of the gastrointestinal tract play a very important role in the health of human. However, when human getting old, the body's functions will decline and so does the intestinal functions. This study aimed to investigate the improvement effects of product, combined with phospholipid liposomes and Lactobacillus plantarum, on animal models of constipation and colitis. As the results, the number of feces in the colon of loperamide-induced constipation rats were decreased after treating with different dosages of product. Among them, the 5X groups had the lowest amount of feces (5.00 ± 2.10; p ＜ 0.05). In the colitis model, the disease activity index of mice which treatment with product were significantly lower than that of the dextran sulfate sodium (DSS) group ( p ＜ 0.05) after the 18th day on the experiment. In addition, compared with induced group, not only the malondialdehyde levels in colon of mice but also the superoxide dismutase activities were significant improvement after treating with product ( p ＜ 0.05). Furthermore, the tumor necrosis factor-α, interleukin (IL)-1β and IL-6 levels of the colon of 1X group were significantly lower than that in the DSS group ( p ＜ 0.05). In conclusion, products have the potential to improve constipation or colitis.

並列關鍵字

Lactobacillus plantarum ； phospholipids liposome ； constipation ； colitis ； functions of gastrointestinal tract