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Primary Small Cell Neuroendocrine Carcinoma of the Nasal Cavity after Successful Curative Therapy of Nasopharyngeal Carcinoma: A Case Report

成功治療鼻咽癌後原發性鼻腔小細胞神經內分泌癌-病歷報告

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摘要


頭頸部癌症之病患比其他類型癌症病患有更高的風險產生第二次原發性惡性腫瘤。小細胞神經內分泌癌主要發生在肺部且很少被發現在頭頸部,只有一些少數鼻咽小細胞神經內分泌癌的病例在英文文獻中被報告過。一名53歲的婦女,因鼻咽癌在10年前接受成功的放射治療,有幾星期來從左鼻孔流出鼻血的病史。頭頸部的電腦斷層掃描顯現一個在左鼻腔並伸入上頷骨靜脈竇的腫塊。我們採取了標本並做切片檢查,病理上顯示了小細胞神經內分泌癌。患者接受了一完整的合併化學放射治療。經12個月的追蹤並無局部復發或遠端的轉移。

並列摘要


Patients with head and neck cancer have a greater risk of developing second primary malignant neoplasms than patients with any other type of malignancy. Small cell neuroendocrine carcinoma (SNEC) mainly occurs in the lung, and is rarely found in the head and neck region. Only a few cases of sinonasal SNEC have been reported in the English literature. A woman aged 53 years, who had undergone successful curative radiotherapy for nasopharyngeal carcinoma 10 years earlier, presented with a history of bleeding from the left nostril for several weeks. A computed tomography scan of the head and neck showed a mass in the left nasal cavity with extension into the maxillary sinus. A biopsy specimen was taken and pathology revealed SNEC. The patient underwent a full course of concurrent chemoradiotherapy. No local recurrence or distant metastasis was noted during the 12 months of follow-up.

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