Specific IgE to 5 Different Major House Dust Mites among Asthmatic Children

氣喘兒童對五種主要家塵螨之IgE抗體濃度調查

賴慶嶺(Ching-Ling Lai) ； 徐世達(Shyh-Dar Shyur) ； 吳正裕(Cheng-Yu Wu) ； 張景隆(Ching-Long Chang) ； 朱斯鴻(Szu-Hung Chu)

《Acta Paediatrica Taiwanica》 43卷5期 (2002/10) Pp. 265-270

https://doi.org/10.7097/APT.200210.0265

摘要

氣喘是台灣地區最常見的呼吸道過敏疾病，塵螨造成的過敏與小朋友的氣喘密切相關，本實驗調查氣喘病童五種主要家塵螨血清特异性lgE抗體，有93位年齡3到15歲的氣喘病童參與實驗，五種主要家塵螨Dermatophagoides pteronyssinus(DP屋塵螨)、Dermatophagoides farinae(Df粉塵螨)、Dermatophagoides microceras(Dm微角塵螨)、Euroglyphus maynei(Em梅氏嗜黴螨)，Blomiatropicalis(Bt熱帶五爪螨)，並依血清特異性IgE抗體濃度高低分爲六級，其中1-2級爲輕度過敏，3-4級爲中度過敏，5-6級爲重度過敏，並得到以下結論：有63個氣喘病童至少出現對一種塵螨有血清特异性IgE抗體，這63個氣喘病童對五種家塵螨特异性IgE抗體出現率以Dp(87%)最高，其次爲Df(85%)，Dm(84%)，Em(77%)，Bt(65%)。氣喘病童有Dp, Df，Dm，Bt，塵螨血清特異性IgE抗體以中、重度最多（中度加重度分別佔83.6%，83.4%，81.4%，70.6%)，而對Em爲輕度佔大多數（75%）。未出現Dp及Df任何一種塵特異性IgE抗體，仍有機會出現其他塵螨的特异性IgE抗體，比例分別爲Em(3.2%)，Bt(3.2%)，傳統DP，Df塵螨特異性IgE抗體試驗仍有6.4%機會不能測出被其他種類塵螨致敏感的氣喘病童。

關鍵字

氣喘 ； 家慶螨 ； 特異性lgE抗體

並列摘要

Asthma is one of the most commonly occurring manifestation of allergy in Taiwan. Sensitivity to house dust mites is closely related to childhood asthma. This study was designed to investigate sensitized rates and average concentrations of specific IgE antibodies to 5 major house dust mites (HDMs) among asthmatic children. A total of 93 asthmatic children aged from 3 to 15 years were enrolled to measure their specific IgE concentrations in response to 5 different species of mites: Dermatophagoides pteronyssinus (Dp), Dermatophagoides farinae (Df), Dermatophagoides microceras (Dm), Euro glyphus maynei (Em), and Blomia tropicalis (Bt). The severity of hypersensitivity was classified based on the concentration of specific IgE as mild (0.35-3.5kuA/L), moderate (3.5-50kuA/L), and severe (＞50kuA/L). Sixty-three asthmatic children were found to have specific IgE to at least one mite. The percentage of these 63 children who had specific IgE to Dp, Df Dm, Em and Bt were 87%, 85%, 84%, 77%, and 65%, respectively. Patients with specific IgE to Dp, Df Dm, and Bt, had a high percentage of moderate and severe hypersensitivity (83.6%, 83.4%, 81.4%, 70.6%, respectively). However patients sensitized to Em have relatively lower concentration of specific IgE Ab, with 75% of them in the mild range. Some patients had positive IgE antibody to Em (3.2%), and Bt (3.2%) even though they had none to Dp and Df. We conclude that Dm and Bt are also important mite allergens in atopic children. Conventional testing that assays only for sensitivity to Dp and Df would fail to demonstrate 6.4% of mite sensitized asthmatic children.

並列關鍵字

asthma ； house dust mites ； specific IgE