- 期刊
Effects of Perfluorochemicals for Intrapulmonary Vancomycin Administration and Partial Liquid Ventilation in an Animal Model of Meconium-Injured Lungs
以胎便吸入性肺損傷之動物模式探討使用氟碳化合物來進行肺內給藥（萬古黴素）與部份液體通氣術之效果
摘要
Background: Acute lung injury, such as meconium aspiration syndrome in neonates, may present with exacerbated ventilation and perfusion abnormalities. This can impair the efficacy of intravenous antibiotic therapy in treating pulmonary infection. Intrapulmonary administration via perfluorochemical as a vehicle may adequately deliver drugs, such as the poorly pulmonary-penetrative antibiotic vancomycin, to affect lung regions while maintaining gas exchange and non-toxic serum level. Methods: Twelve newborn piglets were injured with intra-tracheally installed human meconium, and randomly grouped into intravenous group (intravenous injection with vancomycin 15mg/kg, followed by conventional gas ventilation) or intrapulmonary group (intrapulmonary instilled with vancomycin 15mg/kg and perfluorochemical emulsion, followed by partial liquid ventilation). Blood samples were obtained to check vancomycin serum concentrations (0-240 mins). Lung tissues were tested for vancomycin contents. Results: Intrapulmonary group animals had signicantly lower vancomycin serum levels than the intravenous group, but vancomycin contents (198.9±72.5μg/g dry tissue) in lung tissues was significantly higher than in the intravenous group (134.9±39.1μg/g dry tissue) (p＜0.05). Gas exchange and lung compliance in the intrapulmonary group were also significantly better than in the intravenous group. Conclusions: Ferjluorochemical is a good vehicle to deliver vancomycin and maintains gas exchange in severe meconium-injured lungs.
並列摘要
Background: Acute lung injury, such as meconium aspiration syndrome in neonates, may present with exacerbated ventilation and perfusion abnormalities. This can impair the efficacy of intravenous antibiotic therapy in treating pulmonary infection. Intrapulmonary administration via perfluorochemical as a vehicle may adequately deliver drugs, such as the poorly pulmonary-penetrative antibiotic vancomycin, to affect lung regions while maintaining gas exchange and non-toxic serum level. Methods: Twelve newborn piglets were injured with intra-tracheally installed human meconium, and randomly grouped into intravenous group (intravenous injection with vancomycin 15mg/kg, followed by conventional gas ventilation) or intrapulmonary group (intrapulmonary instilled with vancomycin 15mg/kg and perfluorochemical emulsion, followed by partial liquid ventilation). Blood samples were obtained to check vancomycin serum concentrations (0-240 mins). Lung tissues were tested for vancomycin contents. Results: Intrapulmonary group animals had signicantly lower vancomycin serum levels than the intravenous group, but vancomycin contents (198.9±72.5μg/g dry tissue) in lung tissues was significantly higher than in the intravenous group (134.9±39.1μg/g dry tissue) (p＜0.05). Gas exchange and lung compliance in the intrapulmonary group were also significantly better than in the intravenous group. Conclusions: Ferjluorochemical is a good vehicle to deliver vancomycin and maintains gas exchange in severe meconium-injured lungs.
延伸閱讀
- Ting, A. K. D., Chang, H., Tsao, T. C. Y., Chou, M. C., & Su, J. M. (2009). 肺內神經鞘瘤於正子／斷層掃描顯像上增加氟化脫氧葡萄糖之攝取：一病例報告. 胸腔醫學, 24(6), 320-324. https://doi.org/10.29806/TM.200912.0003
- Hsieh, H. J., Lin, S. H., Kung, S. Y., Chu, Y. K., Chang, C. P., & Wang, S. J. (2005). 雙時間點之氟－18-FDG正子電腦斷層造影應用於原因不明性阻塞性細支氣管炎合併器質化肺炎：病例報告. 核子醫學雜誌, 18(3), 161-165. https://doi.org/10.6332/ANMS.1803.005
- 陳泰里)、賴佩君)、Yen-Ta Huang（2022）。吸入式甲氧氟烷對於緩解急性創傷相關疼痛的療效和安全性：隨機對照試驗的系統性文獻回顧與統合分析。台灣實證醫學學會會刊，13(1)，64-78。https://doi.org/10.6864/EC.202207_13(1).0012
- 張祐銓、閻紫宸、曾凱元（2002）。利用氟—18—FDG正子掃描偵測絨毛膜癌病人之肺部轉移。核子醫學雜誌，15(2)，103-105。https://doi.org/10.6332/ANMS.1502.009
- 顏國揚（2002）。比較全身氟-18去氧葡萄糖正子放射斷層攝影與鎝-99m亞甲基雙磷酸骨骼掃描偵測非小細胞肺癌病人骨骼轉移之結果。Mid-Taiwan Journal of Medicine，7(4)，244-249。https://doi.org/10.6558/MTJM.2002.7(4).7