- 期刊
Effects of Lamotrigine Monotherapy on Lipid Peroxidation and the Antioxidant Defense System in Patients with Newly Diagnosed Epilepsy
並列摘要
Background: Conventional antiepileptic drugs can induce oxidative stress. We investigated the effects of lamotrigine (LTG) monotherapy on lipid peroxidation and the antioxidant defense system in patients with epilepsy. Methods: This prospective study comprised 17 patients with newly diagnosed epilepsy and 20 age- and sex-matched controls without evidence of epilepsy. Levels of oxidative stress markers, including plasma malondialdehyde (MDA), total blood glutathione, and non-glutathione free sulfhydryl (thiol) compounds in whole blood, as well as the activities of antioxidant defense enzymes, including copper-zinc superoxide dismutase (CuZnSOD), glutathione peroxidase (GSHPx), and glutathione S-transferase in plasma and erythrocytes were measured at baseline in patients and controls, at the end of a 3-month LTG monotherapy regimen (short-term), and at the end of a 36- month LTG monotherapy regimen (long-term). Results: There were no significant differences between patients and controls in baseline levels of the measured oxidative stress markers or activities of antioxidant defense enzymes. There were also no significant differences in levels or activities between controls at entry into the study and patients after 3 months of LTG monotherapy. However, after 36 months of monotherapy, the activities of CuZnSOD and GSHPx in erythrocytes were significantly lower and the concentration of total glutathione was significantly higher than baseline values in patients and controls. No differences in MDA were noted between the groups at any time point. Conclusion: LTG monotherapy has an insignificant effect on lipid peroxidation in young patients with partial epilepsy.
延伸閱讀
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