Influence of Apolipoprotein E on the Lipid Profile and Postprandial Triglyceride Levels in Brazilian Postmenopausal Women With Artery Disease

Lucia Helena Bonalume Tácito ； Lilian Nakachima Yamada ； Marcela Augusta de Souza Pinhel ； Juan Carlos Yugar-Toledo ； Dorotéia Rossi Silva Souza

《Clinical Medicine Insights: Cardiology》 2017卷 (2017/12) Pp. 1-9-014

https://doi.org/10.1177/1179546817731110

摘要

This study confirms the association of risk factors for coronary artery disease (CAD) and the apoE polymorphisms, specifically related to the APOE*4 allele, with coronary disease in postmenopausal women. Significantly altered values of the lipid profile were found in patients when compared with controls, independent of the presence of the APOE*4 allele. However, the controls showed higher high-density lipoprotein cholesterol (HDL-C) levels and reduced triglyceride (TG) levels, differing significantly from patients. In this case, the study of subgroups, considering the APOE*3/3 and APOE*3/4 genotypes, suggests that the APOE*4 allele is not implicated in the variations of the lipid profile of patients and determined an increase in the production levels of HDL-C and a reduction in TG highly benefiting the control group compared with APOE*3/3 genotype. The metabolic kinetics of TG, although with the same pattern between groups, and the presence of the APOE*4 allele are suggested to be associated with accelerated clearance compared with APOE*3 allele in non-CAD group.

關鍵字

Coronary artery disease ； postmenopause ； apolipoprotein E ； cholesterol ； postprandial triglycerides