- 期刊
中藥方劑豬苓湯對腎性高血壓鼠降壓效果之研究
Anti-hypertensive Effects of Traditional Chinese Medicine Ju-Ling-Tang on Renal Hypertensive Rats
摘要
The blood pressure-lowering effect of the traditional Chinese medicine Ju-Ling-Tang (JLT) was investigated in a hypertensive rat model using unilateral renal artery ligature. Level of self-ambulation 30 min after administration of JLT (240mg/kg) was less than in controls receiving 0.9% NaCl. Rats that were administered 60 and 120 mg/kg JLT had greater ambulatory activity than rats receiving 240 mg/kg JLT. Regarding anti-anxiety effects, onset time required for sleep induction was shorter for animals given 240 mg/kg JLT than in rats administered 35 mg/kg sodium pentobarbital. JLT (240 mg/kg) significantly prolonged sodium pentobarbital-induced sleep time. Sixty minutes after oral administration of JLT (240mg/kg) to hypertensive rats, blood pressure was significantly lowered by 21 mmHg (p ＜0.05) for 120 min. Administration of 50 mg/kg α-methyldopa to the control group reduced blood pressure (reaching 34 mmHg) for 240 min. Norepinephrine (NE) measurements in the rat brain indicated that JLT induced a dose-dependent decrease (p ＜ 0.05) in NE concentration within the cerebral cortex and brain stem. In rats that received 240 mg/kg JLT, pathological examination of the kidneys demonstrated a reduction in glomerular sclerosis in rats with ligated renal arteries compared with controls. Our findings suggest that in cases of hypertension caused by renal pathological changes, JLT has an excellent blood pressure-lowering effect that is closely related to effects of neurotransmitters in the central nervous system.
並列摘要
The blood pressure-lowering effect of the traditional Chinese medicine Ju-Ling-Tang (JLT) was investigated in a hypertensive rat model using unilateral renal artery ligature. Level of self-ambulation 30 min after administration of JLT (240mg/kg) was less than in controls receiving 0.9% NaCl. Rats that were administered 60 and 120 mg/kg JLT had greater ambulatory activity than rats receiving 240 mg/kg JLT. Regarding anti-anxiety effects, onset time required for sleep induction was shorter for animals given 240 mg/kg JLT than in rats administered 35 mg/kg sodium pentobarbital. JLT (240 mg/kg) significantly prolonged sodium pentobarbital-induced sleep time. Sixty minutes after oral administration of JLT (240mg/kg) to hypertensive rats, blood pressure was significantly lowered by 21 mmHg (p ＜0.05) for 120 min. Administration of 50 mg/kg α-methyldopa to the control group reduced blood pressure (reaching 34 mmHg) for 240 min. Norepinephrine (NE) measurements in the rat brain indicated that JLT induced a dose-dependent decrease (p ＜ 0.05) in NE concentration within the cerebral cortex and brain stem. In rats that received 240 mg/kg JLT, pathological examination of the kidneys demonstrated a reduction in glomerular sclerosis in rats with ligated renal arteries compared with controls. Our findings suggest that in cases of hypertension caused by renal pathological changes, JLT has an excellent blood pressure-lowering effect that is closely related to effects of neurotransmitters in the central nervous system.
延伸閱讀
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