Primary Peritoneal Serous Papillary Carcinoma with Brain Metastasis: Case Report

原發性腹膜漿液性乳頭狀癌合併腦部轉移：病例報告

蘇棋楓(Chi-Feng Su) ； 廖瓊玲(Chiung-Ling Liao) ； 陳進典(Gin-Den Chen)

《中山醫學雜誌》 16卷1s期 (2005/06) Pp. 145-152

https://doi.org/10.30096/CSMJ.200506.0018

摘要

原發性腹膜漿液性乳頭狀癌(PPSC)應該被當作晚期的卵巢癌進行積極的治療。一名55歲停經後婦女接受剖腹手術後被診斷出是PPSC伴有大量腹水。患者首先以六期的化學治療（cyclophosphamide和cisplatin）治療，然後再接受癌症減積手術，接著再以另一六期的化學治療（paclitaxel和carboplatin）。治療期間病患出現心情浮動、語無論次以及腫瘤指數CA125速增，由核磁共振圖像顯示為癌症腦轉移。癌康定(topotecan)被應用作為後線搶救療法，因為它可能穿過血腦屏障。最後治療失敗並且患者在PPSC腦轉移三個月後死亡。

關鍵字

原發性腹膜漿液性乳頭狀癌 ； 腦部轉移 ； CA125 ； 癌康定topotecan

並列摘要

Primary peritoneal serous papillary carcinoma (PPSC) should be treated as aggressively as advanced ovarian carcinoma is treated. A 55-year-old postmenopausal woman with PPSC and massive ascites was diagnosed by exploratory laparotomy. The patient was first treated with a six-cycle regimen (cyclophosphamide and cisplatin), then underwent debulking surgery which was then followed by another six-cycle regimen (paclitaxel and carboplatin). Mood changes, speech motor difficulties and a rapid increase in CA125 levels indicated PPSC with brain metastasis which was confirmed by magnetic resonance imaging. Topotecan (Hycamtin(superscript ®)) was prescribed as a salvage therapy and combined with brain radiation because topotecan can penetrate the blood-brain barrier. This treatment failed and the patient expired three months after the diagnosis of PPSC with brain metastasis.

並列關鍵字

Primary peritoneal serous papillary carcinoma ； brain metastasis ； serial CA125 ； topotecan