This paper aims to analyze the existing nursing regulation and provide recommendations for developing a relevant regulation system for registration and practice of nurses in Macau. Literature review and discussion of relevant nursing regulation sand system of different countries and regions were conducted for comparison of the basis and aims of such system in order to reflect on the current condition of Macau. An unified approach which has taken into account the size of the city, a balance between health needs and nurses shortage in the society, the assurance of health service quality is suggested for nurses accreditation and registration in Macau.