Objectives: The purpose of this study was to investigate the current status of physical exercise and health self-management in employees with type 2 diabetes. Methods: A cross-sectional study was employed to investigate 826 employees with Diabetes Mellitus from hospitals of Guangzhou and Chengdu city respectively from February 2018 to August 2018. The general physical exercise questionnaire, Diabetes Self-Management Scale, and analysis were performed to explore their status. Results: The level of physical activity in employees with diabetes mellitus was low. The level of health self-management was moderate, but the proportion of good was low. Conclusion: It is important to assess the physical activity of employees with diabetes mellitus. Their physical activity can be improved, so they can develop a more active lifestyle and improve their overall health.