With the development of information technology, the traditional medical care industry is gradually replaced by interdisciplinary application. Nowadays, nursing staffs are expected to have the basic ability to handle clinical records and care-related information systems. Facing the accelerated establishment of smart medical system in Macao, the trend is to cultivate talent in informatics nursing. This article aims to summarize the development of international informatics nursing and provide a reference for the reformation of nursing education in Macao. As a result, the article contributes to enhancing knowledge of informatics nursing among the nursing profession and thereby promoting the growth of informatics nursing in Macao.