Reduction of Dilated Cardiomyopathy of Broiler Chickens Model by Pharmacological Treatments-Pathological Aspects

藥物減輕人工誘導白肉雞DCM之病理方面研究

吳得進(Der-Jinn Wu) ； 林子恩(James A. Lin) ； 林正盛(Cheng-Sheng Lin)

《臺灣獸醫學雜誌》 33卷1期 (2007/03) Pp. 6-13

https://doi.org/10.7009/TVJ.200703.0006

摘要

To examine the effects of drugs on reduction of DCM in the cold-induced broiler-chicken model. Three-week-old broiler chickens were exposed to cold temperature (14-16℃) for 5 weeks and treated with no drug, perindopril (0.1mg/kg/day), carvedilol (1mg/kg/day), or furosemide (1mg/kg/day). Control chickens were housed at 20-25℃ (room temperature) and assigned to one of the four treatment groups. The heart weight/ body weight ratio was decreased by perindopril and carvedilol and was significantly lower in drug treated versus non-drug treated chickens of the cold-exposure group. RV wall thickness can be reduced by perindopril. The highest cardiac mortality was found in the non-drug treated chickens of the cold-exposure group. Severity of DCM can significantly reduce by the three drugs in cold-exposed chickens. Conclusions: Diuretics, β blockers and angiotensin converting enzyme inhibitors reduce the severity of DCM in the cold-exposure chicken model and can be used to study mechanisms of ventricular remodeling.

關鍵字

擴張型心肌症 ； 低溫誘導 ； 心臟衰竭 ； 白肉雞

並列摘要

To examine the effects of drugs on reduction of DCM in the cold-induced broiler-chicken model. Three-week-old broiler chickens were exposed to cold temperature (14-16℃) for 5 weeks and treated with no drug, perindopril (0.1mg/kg/day), carvedilol (1mg/kg/day), or furosemide (1mg/kg/day). Control chickens were housed at 20-25℃ (room temperature) and assigned to one of the four treatment groups. The heart weight/ body weight ratio was decreased by perindopril and carvedilol and was significantly lower in drug treated versus non-drug treated chickens of the cold-exposure group. RV wall thickness can be reduced by perindopril. The highest cardiac mortality was found in the non-drug treated chickens of the cold-exposure group. Severity of DCM can significantly reduce by the three drugs in cold-exposed chickens. Conclusions: Diuretics, β blockers and angiotensin converting enzyme inhibitors reduce the severity of DCM in the cold-exposure chicken model and can be used to study mechanisms of ventricular remodeling.

並列關鍵字

dilated cardiomyopathy ； cold-exposure ； heart failure ； broiler chicken