The use of methamphetamine in HIV infections induce physical and psychological problems. The primary goal of this current treatment is to change psychology and behavior with the aim of reducing or stopping using methamphetamine to improve their psychosocial functions and return to normal life. This article uses the transtheoretical model of change to assist an HIV-infected person in the outpatient clinic to complete the withdrawal of methamphetamine through behavior changes. From November 12, 2018, to August 21, 2019, after comprehensive nursing assessment including interviews, communication software, and medical records, coping enhancement, readiness for change and powerlessness were identified as the health needs. The patient also depends on methamphetamine but feels guilt, thus motivating him to abstain from addiction. Through behavioral change care, the case was assisted from the preparation phase to the action execution phase to successfully cross the first step drug abstinence. The transtheoretical model was used during this period with strategies including addiction counseling, emotional counseling, and customized health education activities to successfully complete the drug addiction withdrawal of the case. It is hoped that this experience will provide clinical nurse with a reference when performing addiction care for patients.