This case is a fifty-three-year-old female patient, made diagnosis of right breast cancer, T1N0M0, ER(+), PR(+), HER-2/NEU(3+), and then received treatment of surgery and chemotherapy many times. However, because of chemotherapy-induced hand-foot syndrome on and off, she asks us for help. After we treat her with acupuncture , the edema, heat and tightness sensation get improvement, but both of legs are still redness and numb feeling.