造血幹細胞移植後急性移植物抗宿主疾病及其護理

Care of Patient with Acute Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

蕭逸美(Ye-Mei Hsiao) ； 邱倫瑋(Lun-Wei Chiou)

《腫瘤護理雜誌》 13卷2期 (2013/12) Pp. 15-25

https://doi.org/10.6880/TJON.201312_13(2).02

摘要

近年來造血幹細胞移植已有很大的進展，急性移植物抗宿主疾病（acute graft versus host disease，aGVHD）仍然是移植後最常見的合併症。本篇報告主要指出急性移植物抗宿主疾病的致病機轉、危險因子、臨床症狀、分級及預防措施，並討論相關的治療及護理措施。藉由文獻查證提供相關的照護知識給臨床護理人員作為照護上的準則。

關鍵字

移植物抗宿主疾病 ； 造血幹細胞移植 ； 護理

並列摘要

Despite recent advancements in allogeneic hematopoietic stem cell transplantation, graft-versus-host disease (GVHD) still has been the major cause of morbidity and mortality following transplantation. This review paper focuses on the pathophysiology mechanisms, risk factors, clinical presentations, stage and grading, prophylaxis, and treatment of acute GVHD. The standard treatment of acute GVHD involves the intensification of immunosuppressive therapy with adequate topical supportive management. A review of the adverse events follow transplantation unmasks the need of evidence-based medical and nursing practice to improve the quality of the holist care for these patients who received allogeneic hematopoietic stem cell transplantation.

並列關鍵字

graft-versus-host disease ； allogeneic hematopoietic stem cell transplantation ； nursing