天蘿水之毒性及致突變性測試

The Toxicity and the Mutagenesis Ability of Tain-Luo-Shui

黃柏憲(Po-Hsien Huang) ； 曹偉(Wei Tsauer) ； 呂明進(Ming-Chin Lu) ； 李勝吉(Sheng-Chi Lee) ； 張瑞璋(Jui-Chang Chang) ； 蔡金川(Chin-Chuan Tsai)

《臺灣中醫醫學雜誌》 5卷1期 (2006/06) Pp. 27-40

https://doi.org/10.30032/TJCM.200606.0004

摘要

天蘿水(Tain-Luo-Shui)，異名絲瓜水、絲瓜露，是臺灣雲林、嘉義地區的農業特作，民間常用於去黯美白、消炎去痤、治療肺炎或急性痛風發作等用途。絲瓜露相關產品甚多且也廣被民眾所接受，但其相關的研究資料卻是有限，本研究室已証實其具有顯效的抗氧化及抗自由基作用，是個具有開發潛力的化妝品原料。為了提供完整的安全性評估，本實驗繼而執行絲瓜露之致突變試驗(Ames test)和細胞毒性試驗(MTT test)。實驗結果顯示絲瓜露對於沙門氏桿菌不具致突變性，而高劑量則有毒性作用；對人類皮膚纖維母細胞及角質細胞無細胞毒性反應，甚至有促進生長的作用，顯示擁有促進皮膚修復潛能。

關鍵字

天蘿水 ； 絲瓜露 ； 致突變 ； 細胞毒性

並列摘要

Tain-Luo-Shui, which is also named the sponge gourd water or the sponge gourd gel indicating that it is Luffa cylindric (L.) Roem. originally, is commonly seen in the Yun-lin and Cha-Yi counties in Taiwan. It is used for whitening, subduing the fire of phlegm, detoxifying, cleaning the hot inside the body, curing lung carbuncle and impotence. Although the products of Tain-Luo-Shui have been widely accepted; however, its experimental data are scarce. My laboratory has demonstrated that the Tain-Luo-Shui has anti-oxidant and anti-free radical capacity, being a potential material for cosmetics. In the present study, we further performed the Ames test and the MTT test to provide detailed data for safety reason. Results showed that the Tain-Luo-Shui would not cause the mutation of the Salmonella. High dose of the Tain-Luo-Shui even had bactericidal capability. As it was applied to the fibroblast and the keratinocyte, no toxicity was detected. On the contrary, it could promote the regeneration of both the cells, showing its potential capability to repair damaged skin.

並列關鍵字

Tain-Luo-Shui ； Luffa cylindric L. ； toxicity ； mutagenesis