We reported a female patient who visited our out-patient-department of Chinese medicine due to insomnia for two months, and made the discussion of pathophysiolgy and recording of the progress. First, we differentially diagnosed the symptoms according to the ancient literature individually and then concluded a core pathophysiology. Second, we recorded the changes of the disease and symptoms, and reviewed the prescription. The two stages of the treatment were: ”supplying the yin-yang of kidney, calming down the compensated heat” and ”supplying the yin-blood of liver, supplying the qi and yin of kidney”, and we improved the insomnia and other symptoms in three weeks. Through this case report, we could provide a clinical workbench of diagnosis and treatment, and we also knew that the practice of ”seeking the reason and giving the right remedy” certainly is absolutely a key-point of getting a good clinical effects.