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Vancomycin Resistant Enterococci (VRE) from Intracolonic Use of Vancomycin for Pseudomembranous Colitis

在偽膜性大腸炎病患使用病患使用萬古黴素腸內灌洗後發現具萬古黴素抗藥性之腸球菌

摘要


偽膜性大腸炎是困難狀桿菌所引發的,隨著抗生素使用增加,這個疾病也變的更加容易出現。通常偽膜性大腸炎可以用口服萬搶黴素或是甲硝唑來治療。我們報告一個六十八歲的女性病人。她因為罹患了嚴重的偽膜性大腸炎,而需要接受哈特曼氏手術,術後並進行大腸內萬古黴素灌洗。然而卻因此導致了具萬古黴素抗藥性腸球菌,以及全抗藥性包曼氏桿菌的滋生。在停用萬搶,以及充分的支持療法之後,病人的感染漸漸消逝。隨著抗生素的廣泛使用,細菌的抗藥性變成一個嚴重的問題。選擇適當的抗生素,並且在適當的時機進行手術治療,才能避免產生惡性循環。

並列摘要


Pseudomembranous colitis is caused by Clostridium difficile, and has become more common with increasing antibiotic use. Pseudomembranous colitis can usually be treated with oral vancomycin or metronidazole. We report the case of a 68-year-old woman with severe pseudomembranous colitis who required a Hartmann’s procedure, after which intracolonic vancomycin was administered. This resulted in vancomycin-resistant enterococci, and pan-drug resistant Acinectobacter baumanii infection. After discontinuation of the vancomycin and supportive care, the infection subsided. With the increasing use of antibiotics, drug resistance poses an important problem. And the vicious cycle can be only avoid with adequate antibiotics use and proper timing of surgical intervention.

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