In Taiwan, we are now experiencing a second wave of the SARS-CoV-2 epidemic, which is predominantly caused by the omicron variant in our community. According to epidemiology, it is not surprising that cases have increased rapidly in the population aged <18-year-old. Although most cases are mild and self-limiting, several children infected by the omicron variant develop severe encephalitis, resulting in a high mortality rate in our country. Therefore, increasing the vaccine coverage rate in this population is an important and urgent concern. Furthermore, we should continue to investigate possible risk factors and effective treatment protocols for those suffering from severe encephalitis after infection with the omicron variant of SARS-CoV-2.