以環糊精來改善葛根萃取物在纖維素膠體中的相容性

Amelioration of Rhizoma Puerariae Extract Compatibility in Cellulose Gum by Different Cyclodextrin

楊詩韻(Shih-Yun Yang) ； 尤善臻(Shan-Chen Yu)

《美容科技學刊》 7卷1期 (2010/03) Pp. 89-105

https://doi.org/10.30001/JIES.201003.0007

摘要

環糊精(cyclodextrin, CD)是一種中空筒狀化合物，由於它外部親水，並且能將一些難溶解於水的藥物包裹在其親油性空腔中，從而能提高中草藥萃取物的水溶性，以及掩飾其臭味，和延長其在溶液中釋放的效果。然而，在添加環糊精有時也會導致劑型不相容的現象，如產生沉澱或使乳液或膠體流體化。
本研究將探討添加環糊精以改善葛根萃取物(RX-25)，一種用於豐胸產品中的有效成分，在數種膠體的溶解度情形。結果發現在正確的濃度下添加適合及適量的環糊精可以幫助改善含有中草藥萃取物的劑型配方的外觀、黏稠度與安定性。

並列摘要

cyclodextrins (CD) are often used to increase the water solubility, to mask the odor, and to prolong the liberation in solutions of nature Chinese herb extract. It is due to natural CD arrangement, their toroid shape has hydrophilic exterior and hydrophphobic interior allowing complexation with hydrophobic molecules. However, CDs could cause mcompatibility such as precipitation or fluidization in cream or gel formulations.
In this study, the solubility amelioration of the Rhizoma Puerariae extract (RX-25) which was commonly used in Breast Enlargement product, by CD in several cellulose gums will be investigated.