囊泡載體包覆甘蔗皮萃取液之功效性研究

本研究取甘蔗皮萃取液，以Span20非離子型界面活性劑，添加植物甾醇以5:1之比例製備成囊泡載體進行功效性評估。實驗取2 g紫紅色甘蔗皮粉末加入10% Butylene Glycol水溶液以超音波加微波之複合式方法萃取出甘蔗皮多醣與多酚。結果顯示，多醣萃取率為42.0±3.8%，多酚率為2.10±0.1%。此外，Span 20添加植物甾醇製備之囊泡，第1天粒徑為112.20±2.98 nm，第28天時其粒徑為135.43±1.42 nm，此結果說明配方經過28天高、低溫度虐待實驗，囊泡載體具有相當之安定性；囊泡載體塗抹於皮膚上28天後，皮膚角質層保濕度提升31%；依前述結果說明，Span20添加植物甾醇包覆甘蔗皮萃取液製備之囊泡，具有相當之安定性及功效性，未來可做為化妝品之材料。

關鍵字

甘蔗皮；超音波；微波萃取；植物甾醇；囊泡載體

並列摘要

This research utilizes sugarcane peel extract for efficacy assessment of a niosome prepared by mixing Span 20 non-ionic surfactant with phytosterol at a ratio of 5:1. For the experiment, an aqueous solution of 10% Butylene Glycol was added to 2g of purple-red sugarcane peel powder to extract sugarcane peel polysaccharide and polyphenol by adopting a composite ultrasound and microwave extraction method. The results of the experiment indicate polysaccharide and polyphenol extraction rates of 42.0±3.8% and 2.10±0.1%. In addition, the particle size of niosome prepared by adding phytosterol to Span 20 increases from 112.20±2.98 nm on the 1^(st) day to 135.43±1.42 nm on the 28^(th) day. This result demonstrates that the niosome of the formula exhibits considerable stability after 28-day thermal abuse testing (at high and low temperatures). 28 days after applying the niosome to the skin, the moisture level of the stratum corneum is 31% higher than before. The aforementioned results clearly show that the stability and efficacy of niosome prepared by mixing Span20 with phytosterol encapsulating sugarcane extract is considerably high and may therefore be used as a cosmetics ingredient in the future.