Using Quetiapine for the Treatment of Methamphetamine-induced Psychosis

Quetiapine治療甲基安非他命精神病

林式穀(Shih-Ku Lin) ； 潘俊宏(Chun-Hern Pan)

《北市醫學雜誌》 9卷4期 (2012/12) Pp. 388-392

https://doi.org/10.6200/TCMJ.2012.9.4.08

摘要

目的：長期使用甲基安非他命可能會導致精神病。愈來愈多的文獻指出第二代抗精神病劑quetiapine可以有效的治療物質和酒精使用障礙症。方法：本研究以quetiapine治療七位甲基安非他命引發精神病患者。結果：他們的平均年齡為30.4±8.0歲，平均使用8.6±3.5年。治療前的基準正向與負向症狀量表分數為68.9±20.3，在四週的治療後降為42.6±12.6。第四週quetiapine的平均使用劑量為每天264.3±137.6毫克。患者在此一藥物的劑量治療下其耐受度良好。結論：我們建議以quetiapine來治療安甲基非他命引發精神病是合適的。

關鍵字

甲基安非他命引發精神病

並列摘要

Objectives: Long-term and regular use of methamphetamine can induce psychosis. Growing evidence suggests that the second generation antipsychotic drug quetiapine may be useful as a treatment for substance and alcohol use disorder patients. Methods: We report the use of quetiapine to treat seven cases of methamphetamine-induced psychosis (MIP) in an acute inpatient setting. Results: The mean age of the patients was 30.4±8.0 years old and they had a mean duration of methamphetamine use of 8.6±3.5 years. The mean baseline score for the positive and negative syndrome scales was 68.9±20.3, and this was decreased to 42.6±12.6 after 4 weeks of treatment at a mean dose of quetiapine of 264.3±137.6 mg/day. The patients tolerated this medication well. Conclusion: Quetiapine shows efficacy and its use seems to be beneficial when managing MIP.

並列關鍵字

quetiapine ； methamphetamine-induced psychosis