- 期刊
Omega-3不飽和脂肪酸無法改善輕度認知功能障礙老年人的認知功能
Omega-3 Unsaturated Fatty Acids Do not Improve the Cognitive Function of Elderly with Mild Cogitative Impairment
摘要
隨著人口老化，認知功能衰退為老年醫學的重要議題。現今對於輕度認知障礙的老年人僅建議透過調整生活型態及控制相關危險因子來延緩病情惡化。由於目前無有效治療藥物，許多研究開始探討不同營養補充品是否可改善老年記憶功能，其中補充含有omega-3 不飽和脂肪酸產品為常見方式之一。本報告參考2016 年臺灣醫策會主辦之實證醫學文獻查證臨床組情境，描述醫療人員如何依照實證醫學方式回覆情境病人及家屬，目前omega-3 不飽和脂肪酸無法改善輕度認知功能障礙老年人的認知功能。我們同時回顧此議題相關文獻，並介紹實證醫學步驟與臨床應用。
並列摘要
The degeneration of cognitive functions in elderly has become an important issue in gerontology along with the aging society. Current recommendations for slowing down disease progressions in elderly with mild cognitive impairments (MCI) only suggest lifestyle modifications and control of related risk factors. Due to the lack of effective pharmacological treatments, many studies have started to explore the efficacy of nutritional supplements in the improvement of cognitive functions, and one of these common supplements is omega-3 unsaturated fatty acids. This report followed the clinical scenario of the evidence-based medicine contest in The 2016 Healthcare Quality Improvement Campaign organizing by Joint Commission of Taiwan, and demonstrated how clinical health care providers adopted evidence-based medicine (EBM) methods to search up-todate evidence to prove that supplements of omega-3 unsaturated fatty acids do not significantly improve the cognitive functions in aged patients with MCI. Moreover, we reviewed related literature and introduced the procedures and clinical implications of EBM in this report.
延伸閱讀
- Lin, Y. T. (2021). 運動或攝取omega-3脂肪酸及相結合對老年人認知執行功能的影響－文獻回顧. 中原體育學報, (16), 33-41. https://doi.org/10.6646/CYPEJ.202107_(16).0004
- Chang, J. P. C., & Su, K. P. (2010). 脂筏(lipid raft)理論的觀點：Omega-3多元不飽合脂肪酸與憂鬱症及心血管疾病之關係. 臺灣精神醫學, 24(3), 168-180. https://doi.org/10.29478/TJP.201009.0003
- Kuwabara, A., Himeno, M., Tsugawa, N., Kamao, M., Fujii, M., Kawai, N., Fukuda, M., Ogawa, Y., Kido, S., Okano, T., & Tanaka, K. (2010). 居住機構中的老年人有高盛行率的維生率D及維生素K缺乏症且與整體的營養不良無相關. Asia Pacific Journal of Clinical Nutrition, 19(1), 49-56. https://doi.org/10.6133/apjcn.2010.19.1.07
- Wahlqvist, M. L., Xiu, L., Lee, M. S., Chen, R. C. Y., Chen, K. J., & Li, D. (2016). 飲食多樣性無法抵銷高同半胱氨酸血症老年糖尿病患者的死亡風險：一個前瞻性世代研究. Asia Pacific Journal of Clinical Nutrition, 25(2), 414-423. https://doi.org/10.6133/apjcn.112015.06
- Laake, K., Seljeflot, I., Fagerland, M. W., Njerve, I. U., Arnesen, H., & Solheim, S. (2015). Effects on Serum Fractalkine by Diet and Omega-3 Fatty Acid Intervention: Relation to Clinical Outcome. Mediators of Inflammation, 2015(), 659-664-161. https://doi.org/10.1155/2015/373070