In this report, we present a 54-year-old woman who suffered from persistent numbness and weakness of both upper extremities after cervical spine operation for spinal stenosis due to degenerative changes of the cervical vertebrae, spondylolisthesis, and herniated intervertebral discs. She received several courses of physical therapy soon after the surgery, but the effect was limited. Therefore, she visited our acupuncture department to seek for helps. Both numbness and weakness over her hands immediately alleviated after each session of acupuncture, and although the symptoms partially rebounded several days after the treatment, the overall severity gradually decreased with further sessions of acupuncture. At her last visit, she could clamp her fists firmly and perform some daily activities with ease which was not possible before or just after the surgery. This case demonstrated that acupuncture may serve as an alternative therapeutic option in the treatment of post-surgical spine syndrome.