有助於減緩COVID-19病人症狀與減少住院時間的醫用高濃度氫氧氣之回顧

2019年冠狀病毒病Coronavirus Disease 2019（COVID-19）不僅對患者的呼吸系統與肺組織造成傷害，也有機率攻擊感染者的心血管系統而引起眾多心血管併發症，更可能造成患者隱形缺氧。經由臨床試驗與研究顯示吸入高流量與高濃度氫氧混合氣（比率66%氫氣：34%氧氣）可改善COVID-19患者呼吸系統症狀與減少住院天數，並可能降低COVID-19病毒對心血管系統的衝擊。如何提供穩定、安全的高流量／高濃度氫氧混合氣供COVID-19患者於醫院、檢疫旅館、隔離中心或居家隔離使用，以降低對於醫療資源的衝擊成為一項重要課題。

關鍵字

COVID-19冠狀病毒；氫氧混合氣；呼吸道疾病；心血管疾病

並列摘要

Coronavirus disease 2019 (COVID-19) causes damage to the respiratory system and lung tissues. There is a risk that the cardiovascular system might be attacked and lead to numerous cardiovascular complications and even invisible hypoxia. Clinical trials and research have shown that inhalation of high flow rate/concentrations of hydrogen/oxygen mixture gas (66% hydrogen: 34% oxygen) can significantly improve respiratory symptoms and reduce hospitalization days and possibly its impact on the cardiovascular system. Therefore, providing stable and safe hydrogen/oxygen mixture gas for COVID-19 patients isolated in hospitals, quarantine hotels, isolation centers, or their own homes to reduce the impact on medical resources has become a critical issue.

並列關鍵字

COVID-19 coronavirus ； hydrogen/oxygen mixture gas ； respiratory disease ； cardiovascular disease

參考文獻

Gao Y, Yang H, Fan Y, et al., Hydrogen-rich saline attenuates Cardiac and Hepatic Injuries in Doxorubiein Rat model by inhibiting inflammation and apoptosis. Mediators Inflamm 2016; 2016: 1320365.

Elsevier. COVID-19 and vascular disease. EBioMedicine 2020; 58: 1029662.

Xuejun S, Shigeo O, Atsunori N. Hydrogen Molecular Biology and Medicine. Heidelberg: Springer Netherlands; 2015.

Hayashida K, Sano M, Ohsawa I, et al. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun 2008; 373(1): 30-35.

Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 2007; 13(6): 688-94.

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