This article was the application of Watson's caring theory in nursing experience in a child with Enter virus infection and the mother. The nursing period was from January 9th to 14th, 2009. Direct observation and talks were utilized on holistic nursing assessment to understand what questions were frequently asked by the child patient with Enter virus infection and what pressures and demands the mother were facing. The results through the assessment showed that the main problems on nursing were hyperthermia, oral mucosal damage and caregiver strain. Watson's caring theory was utilized by the author for the guidance and accordance in nursing process, to promote comfort of the child patient, to reduce anxiety due to hospitalization, to relieve emotional stress of the mother, and to provide family-centered nursing.