Takotsubo cardiomyopathy is a syndrome consisting of acute-onset, transient, and abnormal left ventricular wall motion with apical akinesis and basal normokinesis without angiographically significant coronary artery stenosis. The clinical manifestations are similar to acute myocardial infarction, such as electrocardiogram (ECG) changes (ST-segment elevation and subsequent giant T wave inversion) or abnormal myocardial enzymes. The underlying pathophysiology remains unclear though there are many etiologies for this syndrome that have been proposed. We reported a 38-year-old woman with ampulla cardiomyopathy precipitated by epileptic seizure. We proposed that catecholamine-related microcirculation dysfunction appears to be the most likely etiology.