The prevalence of chronic obstructive pulmonary disease (COPD) in Taiwan is about 16% of the adult population aged 40 years and older. In the world, COPD is the fourth leading course of death. The trend of increasing prevalence and death rate of COPD is marked in the future. Patients with end-stage COPD are most likely to be admitted three to four times per year with exacerbations of COPD. Currently there is a lack of palliative care provision for patients with end-stage COPD compared with lung cancer patients despite having twice the odds of being admitted to an intensive care unit, poor prognosis, intolerable dyspnea, greater disability and poor quality of life. We share the experience of assisting a patient with end-stage COPD to withdraw ventilator in legal, ethical and emotional issues for reference to hospice palliative care team.