癌因性疲憊相關之病理生理機轉

Mechanisms and Pathophysiology Related to Cancer-Related Fatigue

趙基安(Chi-An Chao) ； 許名雅(Ming-Ya Hsu) ； 陳虹汶(Hong-Wen Chen) ； 蘇文浩(We-Hao Su) ； 黃麗卿(Lee-Ching Hwang) ； 鄒孟婷(Meng-Ting Tsou)

《安寧療護雜誌》 16卷3期 (2011/11) Pp. 348-360

https://doi.org/10.6537/TJHPC.2011.16(3).6

摘要

癌因性疲憊是癌症病人所經驗到最常見且複雜的症狀之一，不僅讓病人非常困擾，對生活品質亦造成極大的影響。本篇論文針對癌因性疲憊的機轉及病理生理學，進行廣泛的文獻回顧，目前被提出的機轉包括：促發炎性細胞激素失調、下視丘-腦垂體-腎上腺軸功能障礙、血清素失調、晝夜節律失調、貧血、三磷酸腺苷代謝異常、迷走神經傳入活化、生長因子假說及基因的影響。透過機轉的進一步釐清，當有利於臨床醫師在癌因性疲憊的診斷、預防及處置方面有更進一步的研究。

關鍵字

癌因性疲憊 ； 機轉 ； 病理生理學 ； 癌症

並列摘要

Cancer-related fatigue (CRF) is one of the most common and complex symptoms experienced by patients with cancer. It is one of the most distressing symptoms and can diminish quality of life profoundly. This article mainly focuses on the current hypothetic mechanisms and pathophysiology of cancer-related fatigue. The proposed mechanisms include proinflammatory cytokine hypothesis, hypothalamic-pituitary-adrenal-axis dysfunction, serotonin dysregulation, circadian rhythm modulation hypothesis, anemia, adenosine triphosphate hypothesis, vagal-afferent-activation hypothesis, growth factor hypothesis and genes. These mechanisms provide a basis for future research of CRF and provide new routes for clinicians to develop diagnosis, prevention and further treatment.

並列關鍵字

cancer-related fatigue ； mechanism ； pathophysiology ； cancer