This paper presents a new method of using the theory of topology optimization and PID control theory to design a microgripper system, with a piezoelectric ceramic driver (PZT) microactuator. This study uses a PZT of 5 mm length, 3 mm width, and 0.5 mm thickness, and analyzes the different performances under the application of different voltages. This study defines a compliant amplifier design domain as 9.2 mm × 8.1 mm, with a 0.5 mm thickness, and discusses the effects of different optimization parameters. The driver is a PZT, which can actuate 10.46μm output displacement of the compliant microgripper. A PID controller is designed for the system, and obtains an improvement of the hysteretic characteristics and control performance of the system.