The study aimed at exploring the relationship between job stressors and job satisfaction, as well as whether personality and core self-evaluation may moderate such relationship. The determinants of job stressors examined in this study include: interpersonal conflict, work overload, work autonomy, organizational climate. Using a self-administered questionnaire, a total sample of 89 students with fulltime job was surveyed. Results showed (1) extraversion can moderate interpersonal conflict, work overload, and work autonomy on job satisfaction, (2) agreeableness can moderate the relationship between interpersonal conflict and job satisfaction, (3) conscientiousness can moderate the influence of work autonomy on job satisfaction, and (4) core self-evaluation can moderate the relationship between interpersonal conflict and job satisfaction.