運動對淋巴T細胞亞群CD4+、CD8+之影響

The Relationship between Physical Exercise, CD4+ and CD8+

劉懿娟(Yi-Chuan Liu) ； 莊瑞焜(Jui-Kun Chuang) ； 謝錦城(Chin-City Hsieh)

《運動生理暨體能學報》 7輯 (2008/05) Pp. 15-27

https://doi.org/10.6127/JEPF.2008.07.02

摘要

輔助型T細胞(CD4+)及抑制型T細胞(CD8+)在免疫系統中佔有樞紐位置。本文首先探討運動與免疫機能之關係，其次比較運動對CD4+與CD8+之影響及CD4+/CD8+比值實驗結果。指出規律且中強度運動，可提升CD4+/CD8+比值，增加人體免疫力；劇烈及力竭性運動，體內CD4+與CD8+的比例及數量重新分配，導致免疫系統抑制，免疫力降低，增加上呼吸道感染機率。提供未來臨床訓練計畫監控的指標，作為開立運動處方的依據，闡述受試者體內免疫指標之可能交互機制，減少體內有害因子的產生。同時建議進一步調查，確定運動對健康和疾病的衝擊、關聯及相關機制，對於免疫系統機轉的認識與全民健身將會具有相當的效益。

關鍵字

運動 ； 淋巴T細胞亞群 ； CD4+ ； CD8+

並列摘要

The helper T-cell (CD4+) and the suppressor T-cell (CD8+) holds the key position in the immunity system. In this review, we first investigated relations the exercise and the immunity function, the second to analyze the research effects of exercise influence of and CD4+/CD8+ ratio experiment result to CD4+ and the CD8+. The result revealed that the rule of moderate and submaximal exercise, may promote the CD4+/CD8+ ratio, increases the immunity; acute and exhaustion exercise, in vivo CD4+ and the CD8+ proportion and the quantity redistribute, causes the immunity system suppression, the immunity to reduce, increase upper respiratory tract infection probability. We also recommended to the further research about the test effects of the future clinical training plan monitoring the target, the achievement draws up the exercise prescription the basis, elaborated the possible interactive mechanism to refer the trying in vivo immunity target, reduces in vivo harmful factor the production. Simultaneously will suggest further investigates, the definite movement to the health and the disease impact, the connection and the correlation mechanism, will be able to have the suitable benefit regarding the immunity system turning point understanding and the all the people healthy body.

並列關鍵字

physical exercise ； T-lymphocytes subset ； CD4+ ； CD8+

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